| 1 | 8.74 | Felix Jones (133 rushes, 1,156 yards) | 2007 |
| 2 | 7.62 | Jerry Eckwood (104 rushes, 792 yards) | 1975 |
| 3 | 7.58 | Felix Jones (154 rushes, 1,168 yards) | 2006 |
| 4 | 6.54 | Dickey Morton (127 rushes, 831 yards) | 1971 |
| 5 | 6.5 | Raheim Sanders (222 rushes, 1,443 yards) | 2022 |
| 6 | 6.48 | Knile Davis (204 rushes, 1,322 yards) | 2010 |
| 7 | 6.40 | Mike Washington Jr. (167 rushes, 1070 yards) | 2026 |
| 8 | 6.34 | Ben Cowins (183 rushes, 1,162 yards) | 1976 |
| 9 | 6.32 | Dennis Johnson (106 rushes, 670 yards) | 2011 |
| 10 | 6.32 | Darren McFadden (176 rushes, 1,113 yards) | 2005 |
| 11 | 6.32 | Felix Jones (99 rushes, 626 yards) | 2005 |
| 12 | 6.16 | Rakeem Boyd (184 rushes, 1,133 yards) | 2019 |
| 13 | 6.15 | Geno Mazzanti (123 rushes, 757 yards) | 1949 |
| 14 | 6.03 | Oscar Malone (99 rushes, 571 yards) | 1994 |
| 15 | 6.00 | Jonathan Williams (150 rushes, 900 yards) | 2013 |
| 16 | 5.97 | Rakeem Boyd (123 rushes, 734 yards) | 2018 |
| 17 | 5.84 | Chrys Chukwuma (149 rushes, 870 yards) | 1998 |
| 18 | 5.82 | Alex Collins (271 rushes, 1,577 yards) | 2015 |
| 19 | 5.81 | Cedric Cobbs (227 rushes, 1,320 yards) | 2003 |
| 20 | 5.80 | Darren McFadden (284 rushes, 1,647 yards) | 2006 |
| 21 | 5.76 | Cedric Cobbs (116 rushes, 668 yards) | 1999 |
| 22 | 5.74 | Dickey Morton (226 rushes, 1,298 yards) | 1973 |
| 23 | 5.68 | Fred Talley (197 rushes, 1,119 yards) | 2002 |
| 24 | 5.65 | Ike Forte (174 rushes, 983 yards) | 1975 |
| 25 | 5.64 | Jonathan Williams (211 rushes, 1,190 yards) | 2014 |
| 26 | 5.63 | Darren McFadden (325 rushes, 1,830 yards) | 2007 |
