Game
| Rank | Interceptions (Game) | Opponent | Year |
|---|---|---|---|
| 1 | 9 | SMU | 1970 |
| 2 | 8 | at SMU | 1951 |
| 3 | 7 | at Texas Tech | 1968 |
| 7 | Rice | 1966 | |
| 5 | 6 | Ole Miss | 2020 |
| 6 | Mississippi State | 2003 | |
| 6 | at Baylor | 1965 | |
| 6 | at TCU | 1964 | |
| 6 | Tulsa | 1963 | |
| 10 | 5 | Florida International | 2007 |
| 5 | Louisiana-Monroe | 2006 | |
| 5 | Wichita State | 1970 | |
| 5 | Texas Tech | 1969 | |
| 5 | Texas | 1955 | |
| 5 | at Rice | 1949 |
